The current study provides evidence that the molecular pathways underlying SBE-mediated alleviation of advanced HCC are listed as follows: (a) The application of SBE could simultaneously modulate HSP90β levels, thus inducing the degradation of vimentin to abolish the EMT of SK-Hep-1 cells and promoting apoptosis to prevent the progression of HCC. Here, VIM is linked to hepatocellular carcinoma.