We further quantified the expression level of HSP90β in the HCC tissue array and indicated that significantly increased levels of HSP90β presented in patients at late stage and metastatic samples while slightly higher levels of HSP90β were showed in the subjects of early stage compared with the control group (Supplementary Figure S1), suggesting that HSP90β may be a promising biomarker in detecting advanced HCC. Here, HSP90AB1 is linked to hepatocellular carcinoma.