Western blot analysis verified that exposure of SK-Hep-1 cells to SBE significantly increased the expression of E-cadherin relative to the control, whereas the levels of N-cadherin and vimentin were significantly downregulated, suggesting that SBE could reverse the EMT of advanced HCC cells into mesenchymal–epithelial transition (MET). This evidence concerns the gene CDH2 and hepatocellular carcinoma.