To address the possibility that a relationship may exist between GALC expression and mitochondrial function in human melanoma, we took advantage of previous experiments performed in our laboratory [15,16], in which we investigated the proteomic profile of the cell extracts of GALC-overexpressing A2058 and A375 human melanoma cell lines harboring the tumor-driving BRAF(V600E) mutation, which is present in approximately 50% of human melanomas [4,5]. The gene discussed is BRAF; the disease is melanoma.