In keeping with what was observed for the top 200 genes whose expression was negatively correlated with GALC mRNA levels in human melanoma specimens, the categorization of the 98 proteins downregulated in upGALC cells indicated that “Citrate (TCA) cycle” was the most enriched KEGG pathway (p value = 3.3 × 10−7). The gene discussed is GALC; the disease is melanoma.