It is worth noticing that, at variance with what we found in the TCGA Skin Cutaneous Melanoma database, the ATG4D, ATAD3A, and MRPL41 encoded proteins do not appear to be significantly downmodulated in our GALC-overexpressing melanoma cells, enforcing the concept that the effect of GALC on mitochondrial plasticity may be context-dependent and related to the genetic heterogeneity that characterizes human tumors, including melanoma. This evidence concerns the gene ATG4D and cutaneous melanoma.