Using two independent strategies, namely, high-density array SNP genotyping (Illumina Omni-1.0 and 2.5 M) and whole-exome sequencing (WES), it was possible to detect small de novo CNVs, including genes for some MED subunits (MED9 and MED15), in a family study of sporadic cases of CAD with conotruncal outflow tract defects, heterotaxy syndrome, and left ventricle defects [33]. The gene discussed is MED15; the disease is coronary artery disorder.