PPARA and age-related macular degeneration: Altogether, despite the fact that our results and the work of others point specifically on the important roles of PPAR and RXR activations in controlling several AMD-pathogenic pathways [42,43,44,45,46,47], the precise effects of many members of the NR family deserve to be studied further in order to better understand the deleterious effects of A2E on RPE cells and in the retina [20].