The MICA 129Met allele, MICA-A9 allele, and 129Met/Met genotype were all associated with SLE susceptibility, and the combination of 129Met/A-9 variants displayed reduced expression of NKG2D and NK cell cytotoxicity but increased IFN-γ production from NK92MI cells [47]. Here, MICA is linked to systemic lupus erythematosus.