ASAH1 and cystic fibrosis: This imbalance was ameliorated following treatment with recombinant human acid ceramidase (rhAC), which attenuated the aberrant inflammation previously observed within the CF population in addition to increasing the proportion of sphingosine within the host plasma membrane, reducing the adherence of both S. aureus and P. aeruginosa to the apical membrane of host epithelial cells [263].