The authors showed that the inhibition of S1PR2 reduced IL-1β, TNFα, IL-6, and S1P production within murine bone marrow cells following exposure to Aggregatobacter actinomycetemcomitans; inhibited infection-induced bone marrow-derived monocyte and macrophage chemotaxis; and suppressed RANKL-induced bone resorption. Here, IL6 is linked to infection.