SLC7A11 and myeloid sarcoma: In addition, xCT mRNA and protein expression levels were upregulated in EAE and MS, both in the CNS and the monocyte–macrophage–microglia lineage [30], while inhibition of xCT attenuated chronic and RR EAE in terms of abrogating the clinical disease and attenuating T cell infiltration, inflammation and myelin loss in the CNS [31].