Similar to our results, an inverse change in p53 and p21 levels in the PBMCs of patients with Alzheimer’s disease was revealed [53], and the suppression of the p53 gene was accompanied by the induction of MAP1B (microtubule-associated protein 1B) during neuronal differentiation in vitro [54]. The gene discussed is TP53; the disease is early-onset autosomal dominant Alzheimer disease.