Analyzing other probiotics that could be used in the PD treatment, a recent study using an established Caenorhabditis elegans (roundworm) model of synucleinopathy was able to show that worms that received the probiotic strain Bacillus subtilis PXN21 hardly formed any alpha-synuclein aggregates, reducing the inflammatory response [121]. This evidence concerns the gene SNCA and synucleinopathy.