The SARS-CoV-2 S protein, in the presence of LPS, can upregulate the expression of proinflammatory (TNFα, IL-6, IL-1β, TLR4) and anti-inflammatory (IL-1ra, IL-10) cytokines, as well as antioxidant enzymes (MnSOD), in whole blood from MS patients in vitro. This evidence concerns the gene TLR4 and myeloid sarcoma.