CD274 and pancreatic intraductal papillary-mucinous neoplasm: We further identified IPMN-associated PDAC (IAPA) as a potential candidate for treatment with anti-PD-L1/PD-1 combined with conventional treatment modalities, as immunosuppression in IAPA seems to be the result of a defect in the APM, further aggravated by PD-L1 expression on APCs and ECs, and not primarily mediated by Tregs as in PDAC.