GLI1 and cancer: PRMT1 is overexpressed in various cancer types, including GBM, and the upregulation of PRMT1 promotes cancer cell proliferation and metastasis by methylating several target proteins such as epidermal growth factor receptor (EGFR), GLI1, Twist1, enhancer of zeste homolog 2 (EZH2), cyclin-dependent kinase 4 (CDK4), and STAT [12].