It has also been reported that misfolded SOD1, with an abnormally folded structure, is involved in the pathogenesis of sporadic ALS (sALS), which accounts for the majority of ALS cases, and free radical damage caused by abnormal SOD1 is presumed to be closely involved in the pathogenesis of sALS [42]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.