Notably, while missense mutations appear more prominent in restrictive cardiomyopathy leading to abnormal protein aggregation in RCM patients [29], FLNC truncation variants (FLNCtv) are a main cause of arrhythmogenic cardiomyopathy (ACM), a disease that leads to progressive heart failure and lethal ventricular arrhythmias in humans [25,30,31,32]. The gene discussed is FLNC; the disease is restrictive cardiomyopathy.