Yao et al. also identified ZDHHC3 as the main acetyltransferase required for the palmitoylation of PD-L1 and showed that the inhibition of PD-L1 palmitoylation via 2-bromopalmitate or the silencing of DHHC3-activated antitumor immunity in vitro and in mice bearing MC38 tumor cells [39]. This evidence concerns the gene CD274 and neoplasm.