The HMGB1/RAGE/IL-8 axis plays a crucial role in neutrophil recruitment into the tumor microenvironment (TME) and NETosis as HMGB1 was found to bind the RAGE receptor on glioma cells, activating NF-κB and upregulating IL-8 expression—an influential neutrophil chemoattractant [132]. The gene discussed is CXCL8; the disease is central nervous system cancer.