Recent findings by Li et al. demonstrated that fibroblast growth factor 19 (FGF19)-induced inflammatory cancer-associated fibroblasts (iCAFs) promote neutrophil infiltration and mediate NET formation in liver metastatic niches via the production of complement C5a and IL-1β, accelerating the liver colonization of colorectal cancer (CRC) cells [133]. The gene discussed is IL1B; the disease is colorectal cancer.