SNORA42 is significantly overexpressed in HCC and suppresses the function of the p53-p21 pathway, which is necessary to induce G1 cell cycle arrest, allowing SNORA42-upregulated HCCs to evade damage control mechanisms and inhibit p53-mediated apoptosis (Table 1) [119,157]. The gene discussed is SNORA80E; the disease is hepatocellular carcinoma.