Zhu et al. found that lncSNHG16, upregulated in diffuse large B cell lymphoma (DLBCL), increased cell proliferation and suppressed apoptosis in DLBCL by sponging, or competitively inhibiting, the 5p strand of MIR497, which disrupted miRNA binding at the 3′UTR region of PIM1, a receptor with a putative regulatory role in cell cycle progression, preventing G0/G1 cell cycle arrest and apoptosis in lymphoma cell lines [228]. Here, PIM1 is linked to diffuse large B-cell lymphoma.