NFKB1 and cancer: Anlys Olivera et al. found that the curcumin analog EF31 is a more potent NF-κB inhibitor than EF24 or curcumin in RAW264.7 macrophages, showing a stronger inhibition of NF-κB DNA binding, nuclear translocation, and pro-inflammatory mediators, along with greater effectiveness in cancer cell lines and minimal toxicity in macrophages [148].