PGAM5 and cancer: Results of a pioneering study by Wang Z et al. showed that Drp1 dephosphorylation at Ser637, an inhibitory phosphorylation site, mediated by the mitochondrial protein phosphatase PGAM5, leading to increased mitochondrial fission, plays a pivotal role in the execution of necroptosis, as indicated by results showing that Drp1 knockdown attenuates necroptosis in HeLa and HT-29 cells, i.e., human cancer cells [29].