Specific factors, such as drug toxicities (i.e., iron chelators), bone marrow hyperplasia, and ischemic damage secondary to vaso-occlusive crisis (VOC), as well as alteration of the hepcidin–ferroportin axis in SCD patients, can be behind differences in the features of bones alterations in the different patient populations. The gene discussed is HAMP; the disease is Schnyder corneal dystrophy.