In the comprehensive analysis involving cells from both high CAD and low CAD groups, our findings revealed that iMo communicated with NK cells, CD4+ cells, CD8+ cells, and B cells (Figure 4A), although cell:cell interactions were most robust between iMo and CD4+ effector/memory cells (defined here as CD4+CD45RA−CCR7−/lo). This evidence concerns the gene CD8A and coronary artery disorder.