Key ligand–receptor signaling pairs, in cells from all subjects from both the high CAD and low CAD groups, included iMo PSGL-1 (SELPLG) with B cells and naive CD4+ and CD4+ eff/mem cells, iMo Galectins with naive CD4+ and CD4 eff/mem cells, CD8+ T cells, and NK cells; and CD86 on iMo with Tregs (Figure 4B). The gene discussed is CD8A; the disease is coronary artery disorder.