However, in HIV-negative patients, the most promising two-marker biosignatures (sIL6R and sIL-2Ra) identified TB with an AUC of 0.76, sensitivity of 53.9% (95% CI 33.4–73.4%), and specificity of 79.6% (95% CI 70.3–87.1%) [129]. Here, IL6R is linked to tuberculosis.