All coDASG_DEGs in pathways such as Porphyrin metabolism, Rheumatoid arthritis, Cytosolic DNA-sensing pathway, and Autophagy—other showed significant downregulation in Eastern pigs involving ATG4A, ATP6V1E1, BLVRB, CCL5, FECH, GABARAP, HMBS, IL15, IL18, IRF7, and UROS (Figure 2C). The gene discussed is ATG4A; the disease is rheumatoid arthritis.