As aforementioned, given that there are limited clinical data available to assess the efficacy of SU monotherapy in oncology compared with PHA, and PHA demonstrates acceptable safety and preliminary evidence of antitumor activity in lung and gastric cancer patients [21,22], we herein selected PHA and further investigated mechanisms by which this c-Met inhibitor modulates the growth of HSC-3 cells. This evidence concerns the gene MET and gastric cancer.