In colorectal cancer tissue, the expression of TNFR2 was correlated with Ki-67 expression [59] and a resistance to adriamycin in breast cancer [60], but the functional consequences of TNFR2 expression and of TNFRSF1B c.587T>G SNV on CM cells remain to be elucidated. This evidence concerns the gene TNFRSF1B and colorectal cancer.