G6PD and Familial prostate cancer: In a study investigating the metabolic changes induced by the bone microenvironment in patient samples and prostate cancer cell lines, it was shown that PPP, and in particular its rate-limiting enzyme G6PD, are upregulated in the bone metastasis of prostate cancer, pointing to the specific role of the bone microenvironment in increasing the expression of G6PD via IL-6 secretion [132].