PRMT5 and neoplasm: Treatment of Jurkat and HUT78 cell lines with CMP5 had little effect on cell proliferation and apoptosis; however, the same dose of CMP5 significantly indicated the suppression of cell proliferation in HTLV-1-infected cell lines for 48 h [42], indicating that the inhibition of PRMT5 activity exerted many types of anti-tumour effect at different pathways.