PRMT5 and hepatocellular carcinoma: Furthermore, it has been reported that PKC-mediated phosphorylation of PRMT5 at Serine 15 enhanced the methyltransferase activity and induced the NF-κB signalling pathway through the interaction of PRMT5 with p65 in colorectal cancer [11], and the inhibition of myosin phosphatase (MP) activity resulted in the high phosphorylation of PRMT5 at Threonine 80 along with the arginine methylation of histones and gene repression in hepatocellular carcinoma [12].