As a control, the suppression of PRMT5 or MEP50 expression in the NDRG2-expressing T-ALL cell lines exhibited limited effects on cell growth inhibition and no degradation of HSP90 client proteins (Figure 1E–H and Supplementary Figure S1C,D), suggesting that the effects of PRMT5/MEP50 activity might be dependent on the expression of NDRG2. This evidence concerns the gene NDRG2 and acute lymphoblastic leukemia.