To investigate the function of the PRMT5/MEP50 heterodimer in NDRG2-downregulated cells, we separately suppressed their expression and examined their effects on HSP90 function in low NDRG2-expressing ATL cell lines (KK1 and SO4) and the high NDRG2-expressing cell lines T cell acute lymphoblastic leukaemia T-ALL (Jurkat and MOLT4). Here, PRMT5 is linked to acute lymphoblastic leukemia.