Furthermore, the decrease in H3R8me2s/H4R3me2s and the increase in HSP90 arginine methylation via the knockdown of NDRG2 expression in NDRG2-expressing T-ALL exhibited sensitivity to CMP5 and HLCL61, along with the degradation of AKT and NEMO. This evidence concerns the gene IKBKG and acute lymphoblastic leukemia.