CD274 and cancer: Once they are equipped with immune-regulatory arms, such as the expression of programmed cell death ligand-1 and CD47, and the potential to generate robust immunosuppressive and physical barriers, called the tumor microenvironment (TME) and consisting of immunoregulatory cells and perhaps a dense stroma, cancer cells overcome host immunosurveillance and develop into a cancer mass [26] (Figure 1).