DES and cardiomyopathy: CRYAB-based development of cardiomyopathies is summarized in Table 1, and it varies between and even within specific mutations, but CRYABD109G and CRYABR120G are associated with desmin-related cardiomyopathies [21,30], while the development of hypertrophic cardiomyopathy due to CRYABR123W could be related to abnormal calcineurin–NFAT signaling [36].