LUM expression in the murine uterus is modulated by estradiol and progesterone in the oestrous cycle [108,109] associated with ECM remodelling in uterine tissues and with degenerative pathological changes; thus, LUM is a biomarker of tissue pathology [110,111] and early stages of ovulation and may represent a therapeutic target in some forms of female infertility [105]. This evidence concerns the gene LUM and female infertility.