TLR2 and immune system disorder: Meanwhile, M. gallisepticum infection induced oxidative stress and mitochondrial dynamic imbalance, triggered the inflammatory response through the TLR-2/MyD88/NF-κB signaling pathway, activated the NLRP3 inflammasome, and induced the secretion of IL-1β [117,118], which is closely related to cell death, immune disorders, and inflammatory diseases [50,119,120].