Meanwhile, M. gallisepticum infection induced oxidative stress and mitochondrial dynamic imbalance, triggered the inflammatory response through the TLR-2/MyD88/NF-κB signaling pathway, activated the NLRP3 inflammasome, and induced the secretion of IL-1β [117,118], which is closely related to cell death, immune disorders, and inflammatory diseases [50,119,120]. This evidence concerns the gene IL1B and immune system disorder.