PRDM9 and glaucoma: In glaucoma, aberrant activity of histone-modifying enzymes, such as histone acetyltransferases (HATs), histone deacetylases (HDACs), histone methyltransferases (HMTs), and histone demethylases (HDMs), has been implicated in neurodegenerative processes and retinal ganglion cell dysfunction [140].