E2F1 and cancer: However, the cell cycle control pathways (defective binding of RB1 mutants to E2F1, aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects) and pathways responsible for the cell G1 phase (Cyclin-D-associated events in G1, G1 phase) were identified among the most deregulated pathways in cells transfected with ISO-miR-1246_a and ISO-miR-1246_G.