Cancer-related pathways were more enriched in dysregulated genes in the ISO-miR-1246_a and ISO-miR-1246_G cases (e.g., “signaling by MET” pathway (enrichment rank ISO-miR-1246_G—1.7, p = 5.47 × 10−8; ISO-miR-1246_a—1.8, p = 4.23 × 10−11), “signaling by Hippo” pathway (enrichment rank ISO-miR-1246_G – 1.8, p = 8.57 × 10−8; ISO-miR-1246_a—1.9, p = 3.96 × 10−8), “PI5P, PP2A, and IER3 regulate PI3K/AKT signaling” pathway (enrichment rank ISO-miR-1246_G—2.7, p = 1.24 × 10−4) etc.). The gene discussed is IER3; the disease is cancer.