The Hippo, PI3K/AKT, and tumor microenvironment signaling pathways, responsible for cell proliferation, migration, and invasion, were more enriched in differentially expressed predicted target genes (LATS2, NRAS, PPP2CB, etc.)in cells transfected with mimics of ISO-miR-1246_a and/or ISO-miR-1246_G. The gene discussed is PPP2CB; the disease is neoplasm.