3xTg mice are one of the most used AD models, accommodating three genes with FAD-associated mutations, the human APP gene carrying the Swedish mutation (KM670/671NL), the human MAPT gene carrying the P301L mutation, and the PS1 gene carrying the M146V mutation, using the Thy1.2 promoter and the endogenous PSEN1 promoter [135]. Here, PSEN1 is linked to Alzheimer disease.