The JNPL3 model was found in the late 1990s and was the first developed AD mouse model carrying an MAPT mutation, which expresses the human 0N4R tau with the P301L mutation that only affects the 4-repeat (4R) tau isoform without changing the isoforms ratio, in which a proline is replaced by a leucine within exon 10, using the mouse prion protein promoter [117,118]. This evidence concerns the gene MAPT and Alzheimer disease.