HPV+OPSCC have greater densities of tumour-infiltrating lymphocytes (TIL), including CD3+ T cells, CD8+ T cells, Treg cells, B cells, and plasma cells, compared to HPV−OPSCC, but importantly and specifically B cells and CD8+ cytotoxic T-cells [129,130,131,132]. This evidence concerns the gene CD8A and neoplasm.