Herein, WAM inhibited the viability of human prostate cancer LNCaP cells and increased the sub-G1 portion, the cleavage of PARP and caspase 3, and the number of TUNEL-positive cells, and inhibited Bcl-2 in LNCaP cells, implying that the cytotoxicity of WAM is mediated by apoptosis in LNCaP cells. The gene discussed is CASP3; the disease is prostate cancer.