Finally, TG2 has a negative effect on the von Hippel–Lindau (VHL) tumor suppressor protein through its cross-linking activity, favoring the release of HIF1α from degradation by proteasomes and increasing vascularization and invasiveness: CHOP-mediated TG2 downregulation disrupts this mechanism, suppressing kidney tumor growth and angiogenesis [132]. Here, TGM2 is linked to kidney neoplasm.