Supporting the role of histone acetylation in EMT-dependent fibrotic diseases, HDAC7 has also been demonstrated to regulate collagen deposition and other ECM protein accumulation in fibroblasts derived from patients affected by systemic sclerosis, and indeed, siRNA-mediated depletion of HDAC7 reduced ECM production in these cells, resulting in an evident decrease in fibrogenesis [10]. Here, HDAC7 is linked to systemic sclerosis.