Recently, it was demonstrated that the blocking of histone/lysine methyltransferases, such as the enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 trimethylation methyltransferase, and SET and MYND domain-containing protein 2 (Smyd2), a histone H3 lysine 36 trimethylation methyltransferase, had a negative effect on EMT and consequently attenuated renal fibrosis [141]. The gene discussed is SMYD2; the disease is renal fibrosis.