Mechanistically, upregulation of the expression of heat stress response (HSR)-related genes, such as heat shock protein family A (Hsp70) member 1B (HSPA1B), Hsp70 member 1A (HSPA1A), and DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1), in response to bortezomib was reported to decrease the proapoptotic effects of bortezomib in multiple myeloma cells [34]. Here, DNAJB1 is linked to plasma cell myeloma.