In fact, a study in ATM-deficient/p53-null cancer cells showed that ATR inhibition with VE-821 resulted in increased cytotoxicity after treatment with a variety of genotoxic agents, including platinum-based drugs, radiation, antimetabolites (gemcitabine), and topoisomerase inhibitors (camptothecin and etoposide). The gene discussed is ATR; the disease is cancer.