PHIP and neurodevelopmental disorder: Loss-of-function mutations in the PHIP gene are associated with the neurodevelopmental disorder Chung–Jansen syndrome [65], which includes dysmorphic features, cognitive dysfunction, aberrant behavior, childhood-onset obesity, and severe childhood obesity related to the inhibition of pro-opiomelanocortin (POMC) expression: a neuropeptide that suppresses appetite [62].