Thus, we believe our data advances knowledge on the biological mechanism behind the efficacy of reperfusion treatment and points to the miRNA involved in reperfusion treatment efficacy as well as their target genes CREB5, OTUD7B, PCDH7, and PHIP, and proteins encoded by these target genes in the neuroprotective role of reperfusion treatment in stroke treatment. Here, CREB5 is linked to stroke disorder.