The cytokine expression of TNF-α and IL-1β was significantly reduced at 12 h and 24 h post infection of cells treated with LPS isolated from JOL2943 (Figure 3A,B), whereas in Hela cells, LPS isolated from JOL2943 induced significantly low TNF-α at 24 hpi and IL-1 at 12 h and 24 hpi (Figure 3C,D). The gene discussed is TNF; the disease is infection.