IMQ-induced psoriatic lesions in TRPV1-deficient mice showed lower mRNA levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-23, S100A8, and CXCL1) and higher mRNA levels of the immunosuppressive cytokine IL-10, compared with their wild-type counterparts [114], suggesting that TRPV1 increases the expression of pro-inflammatory cytokines and reduces the expression of immunosuppressive cytokines in psoriasis, thereby contributing to the development of psoriatic inflammation. This evidence concerns the gene TRPV1 and psoriasis.