Overexpression, gain of function, and activation of channels, including nAChR, TRPV1, TRPV3, TRPV4, TRPM4, and ANO1 in keratinocytes, as well as TRPV1, nAChR, Kv1.3, and KCa3.1 in immune cells, have been associated with the induction of psoriasis. The gene discussed is TRPV4; the disease is psoriasis.