BRCA2 and neoplasm: The deficiency of BRCA1 or BRCA2 tumor suppressors, which play a crucial role in repairing DNA breaks through the promotion of the homologous recombination (HR) DNA repair pathway, and in maintaining the stability of newly synthesized DNA strands by safeguarding stalled replication forks from degradation, also triggers type I IFN signaling and anti-tumor immunity.