For example, lncRNAs, such as Hotair, LUST, anti-NOS2A, MEG9, SNHG4, TUG1, and NEAT1, have been found to be highly expressed in rheumatoid arthritis, while the expression of lnc-HSFY2–3:3 and lnc-SERPINB9–1:2 is reduced in systemic lupus erythematosus (SLE) [159]. The gene discussed is SERPINB9; the disease is systemic lupus erythematosus.