Inhibition of the IL-1R1 signaling pathway has been shown to result in increased incidence and mortality rates of breast cancer in mouse tumor models [244] On the other hand, the overexpression of IL-1β in the stomach has been associated with increased gastric inflammation and cancer [232], and its expression in lung cancer has been found to enhance tumor angiogenesis and growth [245]. The gene discussed is IL1B; the disease is neoplasm.