Finally, SFN-mediated apoptosis involved upregulation of Bax and decreased expression of Bim in non-small cell lung cancer cells [33], while the activation of caspases-8, 9, 4, 3, 7, 6 was observed in melanoma cells exposed to SFN, PEITC, and BITC [34]. This evidence concerns the gene BCL2L11 and melanoma.