GDF2 and pulmonary arterial hypertension: Moreover, another study indicated that daily GDF2 administration had no significant effect on mice bearing a heterozygous endothelial BMPR2 deletion (BMPR2EC+/−) but led to excessive angiogenesis in BMPR2EC−/− mice, which implied that the impact of the GDF2 variant on PAH was associated with the BMPR2 variant [36].