Recently, LRRC1, a cytoplasmic scaffold protein, was identified as an oncogenic factor that contributes to HCC [29,35] and lung cancer [32,36]; other studies have reported that LRRC1 regulates the stemness of breast cancer stem cells to behave as a potential tumor suppressor and that in human mesenchymal stem cells (MSCs) [33], LRRC1 acts as a downstream target of PPARγ that regulates adipocyte differentiation [30]. This evidence concerns the gene LRRC1 and hepatocellular carcinoma.