MITF and melanoma: In alpha-melanocyte-stimulating hormone (α-MSH)-induced B16F10 murine melanoma cells, the extract caused inhibition of the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase-related proteins (TRP1 and TRP2) and cAMP response element-binding protein (CREB) activation by suppressing AKT and extracellular signal-regulated kinase phosphorylation [88].