As reported by Weng et al. [37], Chou et al. [134], and Emingil et al. [135], patients with this polymorphism have an increased tendency to develop periodontitis (including generalized aggressive periodontitis), but on the other hand, a single study indicates that there is no relationship between the presence of the MMP-8-799C/T polymorphism and the risk of periodontitis [136]. This evidence concerns the gene MMP8 and periodontitis.