Transient hyperglycemia, followed by glycemic normalization, led to an increase in NFKB signaling in these cells with the phosphorylation of its p65 subunit, triggering an inflammatory loop with the increased expression of microRNA 27a-3p, which negatively regulates the erythroid-2 nuclear factor (NRF-2). Here, NFE2 is linked to Hyperglycemia.