SOD1 and amyotrophic lateral sclerosis: In 2019, Walczak and co-authors compared ALS patients and control subjects in terms of mitochondrial function and antioxidant enzymes, and they found a decreased expression in ALS patients’ mitochondria complexes I, II, III, and IV proteins; in mitochondrial membrane potential; and in SOD1 and catalase, both antioxidant enzymes [138].